'anonymous' 'anonymous'

2020-3448

Brain energy activation with ketones to prevent alzheimer's disease

Recruiment : open

Participating centers

Last modification : 2025-06-02

STUDY DESCRIPTION

Study summary

A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS). Outcomes: brain energy metabolism, cognition, plasma biomarkers, brain imaging (volumetric, functional, structural) and quality of life will be analyzed before and after the intervention.

Source : Import from center

RECRUITMENT

Participant profile

Age limits

minimum: 55 years old maximum: 80 years old

Participants gender(s)

ALL

Source : Import from center

Medical condition (targeted specialty)

Research domain

Data not available

Selection criterias

Inclusion Criteria:

* The participant must answer Yes to the question ''Do you think your memory is not as good as it was?''
* Have a MoCA Score between 20/30 and 26/30
* Have a QAF score of less than 9/30
* Understand, read and talk French
* Having good visual and hearing acuity

Exclusion Criteria:

* Major cognitive decline or neurodegenerative disease.
* Already consuming a daily medium chain triglyceride or ketone supplement.
* Soy, milk, gluten or allergy to the study product
* Controlled or uncontrolled diabetes
* Uncontrolled chronic disease
* Vitamin B12 deficit
* Clinical anomaly in the blood chemistry profile
* QSP-9 score over 19/27
* Taking an anti-cholinergic drugs
* Recent change in medication
* Active cancer in the last 2 years
* General anesthesia in the last 6 months
* history of alcohol abuse or dependence in the last 2 years
* Participation in other interventional or PET research project
* Unable to undergo an MRI or PET scan
* History of kidney stones or hypercalcemia
* History of cardiovascular events or insufficiency
* Renal failure and / or creatinine \<58 umol or\> 110 umol for men and \<46 umol or\> 92 umol for women or if the GFR (glomerular filtration rate) \<60 ml / min / 1.73 m2
* Chronic disease of the digestive system or intestinal malabsorption (celiac disease, chronic pancreatitis, Crohn's disease, etc.)
* Body mass index \<20 or voluntary weight loss of more than 5% in the last 6 months.

Cohorts

Name	Medical condition	Treatment	Recruitment status
Active group	Participants will be on the active intervention for 6 months	Data not available	Unknown
Placebo Group	Participants will be on the placebo intervention for 6 months	Data not available	Unknown
Open phase on active product	At the end of the 6-month randomized controlled phase, participants will be unblinded and invited to continue on the active product for an additional 3 months.	Data not available	Unknown

Active group

Recruitment status

unknown

Participants will be on the active intervention for 6 months

Placebo Group

Recruitment status

unknown

Participants will be on the placebo intervention for 6 months

Open phase on active product

Recruitment status

unknown

At the end of the 6-month randomized controlled phase, participants will be unblinded and invited to continue on the active product for an additional 3 months.

Current data since : June 02, 2025 20:00

LOCATIONS AND CONTACTS

Main location

Centre hospitalier universitaire de Sherbrooke

SHERBROOKE, QUÉBEC, CANADA

Local recruitment — OPEN

Contact details for recruitment

recherche.cerveau@usherbrooke.ca

819-821-5206

Local project contacts

researchers :

CunnaneS

co-researchers :

LepageM

WhittingstallK

TurcotteÉ

BoctiC

FülöpT

DescoteauxM

Last modification : June 02, 2025
Current data since : 05 May 22:47
Data source : clinicaltrials.gov

Date: 07/05/2026 12:15:40

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Identifier

2020-3448

Title

Brain energy activation with ketones to prevent alzheimer's disease
Source : Import from center

clinicaltrials.gov reference: NCT04466735

Recruiment open

Last modification : 2025/06/02

Participating centers

Centre hospitalier universitaire de sherbrooke

Study type

Interventional

Target population

Medical condition (targeted specialty)

Data not available

Participants profils

Age limits

minimum: 55 years old maximum: 80 years old

Participants gender(s)

ALL

Source : Import from center

Selection criterias

Inclusion criteria

Inclusion Criteria:

Exclusion Criteria:

Source : Import from center

Proposed Therapy or Intervention

Cohorts

Name	Medical condition	Treatment	Recruitment status
Active group	Participants will be on the active intervention for 6 months	Data not available	Unknown
Placebo Group	Participants will be on the placebo intervention for 6 months	Data not available	Unknown
Open phase on active product	At the end of the 6-month randomized controlled phase, participants will be unblinded and invited to continue on the active product for an additional 3 months.	Data not available	Unknown

Active group

Recruitment status

unknown

Participants will be on the active intervention for 6 months

Placebo Group

Recruitment status

unknown

Participants will be on the placebo intervention for 6 months

Open phase on active product

Recruitment status

unknown

At the end of the 6-month randomized controlled phase, participants will be unblinded and invited to continue on the active product for an additional 3 months.

Current data since : June 02, 2025 20:00

Study description

Study summary

Source : Import from center

Locations

Participating centers

1 centers

CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE * **

Sherbrooke

QUÉBEC, CANADA

Local recruitment

Recruiting status: OPEN

Contact details for recruitment

recherche.cerveau@usherbrooke.ca

819-821-5206
Local project contacts

researchers:

CunnaneS

co-researchers:

LepageM

WhittingstallK

TurcotteÉ

BoctiC

FülöpT

DescoteauxM
click here for more information about this center
Cohorts

Centre hospitalier universitaire de Sherbrooke
Data not available

Current data since : February 04, 2026 12:04

Last modification : June 02, 2025
Current data since : 05 May 22:47
Data source : clinicaltrials.gov

Nagano reference: 2020-3448
clinicaltrials.gov reference: NCT04466735

2020-3448

Brain energy activation with ketones to prevent alzheimer's disease

STUDY DESCRIPTION

Study summary

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Medical condition (targeted specialty)

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Cohorts

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Identifier

2020-3448

Title

Brain energy activation with ketones to prevent alzheimer's disease
Source : Import from center

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2020-3448

Brain energy activation with ketones to prevent alzheimer's disease

STUDY DESCRIPTION

Study summary

RECRUITMENT

Participant profile

Age limits

Participants gender(s)

Medical condition (targeted specialty)

Selection criterias

Cohorts

LOCATIONS AND CONTACTS

Main location

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Identifier 2020-3448

Title Brain energy activation with ketones to prevent alzheimer's disease Source : Import from center

Study type

Target population

Medical condition (targeted specialty)

Participants profils

Age limits

Participants gender(s)

Selection criterias

Inclusion criteria

Proposed Therapy or Intervention

Cohorts

Study description

Study summary

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Participating centers

Cohorts

Liked this project?

Related projects

Welcome to Quebec Health Research's help guide.

Identifier

2020-3448

Title

Brain energy activation with ketones to prevent alzheimer's disease
Source : Import from center