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2021-00135

Swiss cardiac amyloidosis registry (swiss-care)
Source : Import from center

clinicaltrials.gov reference: NCT04776824
Cardiac Amyloidosis
Tafamidis
CMR feature tracking
Strain
T1 and T2 Mapping
Outcomes
Source : Import from center
Recruiment partially open
Last modification : 2025/05/05
Study type

Observational


Target population

Medical condition (targeted specialty)

Data not available

Participants profils

Participants gender(s)

ALL

Source : Import from center

Selection criterias

Inclusion criteria

Inclusion Criteria:

* Confirmed diagnosis of amyloidosis w/wo cardiac involvement
* General Consent

Exclusion Criteria:

* Inability to give consent or existence of a written or documented oral refusal of the data subject.\<18 years of age

Source : Import from center

Proposed Therapy or Intervention

Cohorts
Name Medical condition Treatment Recruitment status
Patients with confirmed amyloidosis Confirmed diagnosis of amyloidosis w/wo cardiac involvement Data not available
  • Unknown
  • Patients with confirmed amyloidosis
    Recruitment status
    unknown
    Current data since : May 05, 2025 20:00

    Study description

    Study summary

    Cardiac transthyretin amyloidosis (ATTR), caused by ventricular depositions of misfolded transthyretin, results in an infiltrative cardiomyopathy, progressing from pronounced myocardial wall thickening, diastolic and systolic dysfunction to the development of terminal heart failure. Recently, treatment options for TTR amyloidosis have become available. However costs for therapy are enormous and previous trials were not able to differentiate between patients that might benefit from treatment and those without a need for treatment.

    the investigators study aims to determine markers, as assessed by cardiac magnet resonance imaging (CMR) feature tracking (FT) and T1- and T2- mapping, that might reliably indicate disease severity and could help to identify patients that might benefit from (ongoing) TTR stabilization treatment.

    Source : Import from center

    Cardiac transthyretin amyloidosis (ATTR), the most common amyloidosis form with cardiac involvement, is caused by tissue deposition of misfolded TTR, a transport Protein for thyroxine and retinol. Ventricular depositions of amyloid fibrils results in an infiltrative cardiomyopathy, progressing from pronounced myocardial wall thickening, to diastolic and systolic dysfunction and finally chronic heart failure.

    While treatment options are now available, it remains unclear how to monitor therapy response and disease progression. No makers have been identified that predict outcome prior to initiation of therapy, thus patient selection for therapy remains challenging.

    The investigators study will address these issues and will provide systematically assessed CMR data before and over the course of 18 months after therapy initiation. Clinical and laboratory follow-up will be performed every 3-6 months. The investigators study is based on an open, uncontrolled, structured collection of retrospective and prospective data from all patients diagnosed with amyloidosis at the Inselspital Bern with the aim to follow patients undergoing therapy.

    The investigators hypothesize that CMR feature tracking (FT) and measures of T1- and T2- mapping, such as extracellular volume (ECV) may better correlate with disease severity and help to identify patients likely to benefit from (ongoing) TTR stabilizing therapy. Beside standard CMR assessments, the investigators will use CMR feature tracking to quantify global and regional myocardial function. FT has proven to be an excellent predictor in various cardiomyopathies.

    The proposed study will evaluate the potential of CMR to identify patients likely to benefit from therapy, monitor treatment response and balance individual patient benefit and health care cost.

    Source : Import from center

    Locations

    Participating centers


    Last modification : May 05, 2025
    Current data since : 07 May 00:55
    Data source : clinicaltrials.gov
    clinicaltrials.gov reference: NCT04776824