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SNAP Canada

Staphylococcus aureus network adaptive platform trial (snap): an international multi-centered randomised adaptive platform clinical trial to evaluate a range of interventions to reduce mortality for patients with staphylococcus aureus bacteraemia

Septicemia
Staphylococcus aureus
bacteremia
sepsis
antibiotic
Gram +
cocci
bloodstream infection
infectious diseases
Not applicable
Recruiment partially open
Last modification : 2024/02/04
Experimental drug

Phase III


Target population

Medical condition (targeted specialty)

Cancer stage

Not applicable

Participants profils

Participants gender(s)

Females

Males

Subjects aptitude

Incompetent adult due to sudden circumstances

Incompetent Adult

Adult

Selection criterias

Inclusion criteria

1. Staphylococcus aureus complex grown from ≥1 blood culture
2. Admitted to a participating hospital at the time of eligibility assessment (OR if patient has died, they were admitted to this site anytime from the time of blood culture collection until the time of eligibility assessment)

Exclusion criteria

1. Time of anticipated platform entry is greater than 72 hours post collection of the index blood culture
• Where the time of culture collection is not recorded, the time of laboratory registration of the sample will be used as an alternative
2. Polymicrobial bacteraemia, defined as more than one organism (at species level) in the index blood cultures, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician
3. Patient currently being treated with a systemic antibacterial agent that cannot be ceased or substituted for interventions allocated within the platform (unless antibiotic is listed in Table 1, which specifies allowed antibiotics with limited absorption from the gastrointestinal tract or negligible antimicrobial activity against S. aureus)
4. Known previous participation in SNAP
5. Known positive blood culture for S. aureus (of the same silo: PSSA, MSSA or MRSA) between 72 hours and 180 days prior to the time of eligibility assessment
6. Treating team deems enrolment in the study is not in the best interest of the patient
7. Treating team believes that death is imminent and inevitable
8. Patient is for end-of-life care and antibiotic treatment is considered not appropriate
9. Patient <18 years of age and paediatric recruitment not approved at recruiting site
10. Patient has died since the collection of the index blood culture


Proposed Therapy or Intervention

Study intervention

Vancomycin, Flu(Cloxacillin), Cefazolin, Daptomycin, Benzylpenicillin, Penicillin G

Cohorts
Centre hospitalier universitaire de Sherbrooke
Data not available
Current data since : December 06, 2023 10:21
Centre intégré universitaire de santé et de services sociaux du Centre-Ouest-de-l’Île-de-Montréal
Data not available
Current data since : December 06, 2023 10:21
Centre universitaire de santé McGill
Data not available
Current data since : February 04, 2024 00:07
Centre intégré de santé et de services sociaux des Laurentides
Data not available
Current data since : May 07, 2024 00:15
Centre intégré de santé et de services sociaux de Laval
Data not available
Current data since : October 27, 2023 00:30

Study description

Study summary

The Staphylococcus aureus Network Adaptive Platform trial (SNAP) is a clinical research study that focuses on understanding and improving the management of Staphylococcus aureus infections, which can cause various health issues. It's a platform trial involving multiple sub-studies, each exploring different aspects of S. aureus infections and treatment approaches. SNAP aims to optimize patient care by identifying the most effective treatments and strategies. For specific details, it's best to refer to the trial's documentation and consult healthcare professionals or trial organizers.


Locations

Main center

CENTRE UNIVERSITAIRE DE SANTÉ MCGILL

Montréal

QUÉBEC, CANADA

Local recruitment
Recruiting status: POSSIBLY OPEN
Contact details for recruitment
Data not available
Local project contacts
researchers:
  • M. Cheng

co-researchers:
  • E. McDonald

  • T. Lee

  • I. Malhame

  • J. Brophy

Participating centers

    4 centers
  • CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE

    Sherbrooke

    QUÉBEC, CANADA

    Local recruitment
    Recruiting status: POSSIBLY OPEN
    Contact details for recruitment
    Data not available
    Local project contacts
    Data not available
  • CENTRE INTÉGRÉ DE SANTÉ ET DE SERVICES SOCIAUX DE LAVAL

    Laval

    QUÉBEC, CANADA

    Local recruitment
    Recruiting status: OPEN
    Number of participants to be recruited:
    25
    Local project contacts
    researchers:
    • S. Castonguay

    co-researchers:
    • M. Roussos

    • T. Nguyen

    • O. Haeck

    • M. Bergevin

    • E. Simoneau

    • N. Rivest

  • CENTRE INTÉGRÉ DE SANTÉ ET DE SERVICES SOCIAUX DES LAURENTIDES

    Saint-jérôme

    QUEBEC, CANADA

    Local recruitment
    Recruiting status: OPEN
    Number of participants to be recruited:
    25
    Contact details for recruitment
    Local project contacts
    researchers:
    • S. Poulin

    co-researchers:
    • V. Lapointe

    • J. Talbot

  • CENTRE INTÉGRÉ UNIVERSITAIRE DE SANTÉ ET DE SERVICES SOCIAUX DU CENTRE-OUEST-DE-L’ÎLE-DE-MONTRÉAL

    Montréal

    QUÉBEC, CANADA

    Local recruitment
    Recruiting status: POSSIBLY OPEN
    Contact details for recruitment
    Data not available
    Local project contacts
    Data not available

Last modification : February 04, 2024
Current data since : less than a minute
Data source : Nagano
Nagano reference: MP-37-2022-8057