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STUDY00003098

Inspiratory muscle strength training in adults with obesity
Source : Importé depuis le centre

Référence clinicaltrials.gov: NCT05459636
Recrutement ouvert
Dernière modification : 2025/02/05
Type de recherche

Interventionnel


Population cible

Condition médicale (spécialité visée)

Donnée non disponible

Profil des participants

Sexe(s) des participants

ALL

Source : Importé depuis le centre

Critères de sélection

Critères d'inclusion

Inclusion Criteria:

- Body mass index 30 - 40 kg/m2

Exclusion Criteria:

* Not weight stable (\<5% change in body mass over the past six months)
* Overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus)
* Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \>140 / 90 mmHg; anti-hypertensive medications are permitted)
* Diagnosed obstructive sleep apnea
* Previous bariatric surgery
* Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)
* Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)
* Pregnant (self-reported and confirmed via urine pregnancy test), lactating (self-reported), or post-menopausal (self-reported) females
* Prisoners
* Per the POWERbreathe® company:

* Patients who have undergone recent abdominal surgery and those with abdominal hernia.
* Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnea.
* If a patient is suffering from a ruptured eardrum or any other condition of the ear.
* Patients with marked elevated left ventricular end-diastolic volume and pressure.
* Patients with worsening heart failure signs and symptoms after training.
* If an individual is suffering from a cold, sinusitis or respiratory tract infection, it is advised that they do not use the POWERbreathe device.

Source : Importé depuis le centre

Thérapie ou Intervention proposée

Cohortes
Nom Condition médicale Traitement État du recrutement
High-resistance inspiratory muscle strength training Participants will perform high-resistance inspiratory muscle strength training on a daily basis for eight weeks using a handheld device that produces resistance that increases the effort of breathing in. Donnée non disponible
  • Inconnu
  • Very-low resistance inspiratory muscle strength training Participants will perform very-low-resistance inspiratory muscle strength training on a daily basis for eight weeks using a handheld device that produces resistance that increases the effort of breathing in. Donnée non disponible
  • Inconnu
  • High-resistance inspiratory muscle strength training
    État du recrutement
    unknown
    Very-low resistance inspiratory muscle strength training
    État du recrutement
    unknown
    Données à jour depuis : 5 février 2025

    Description de l'étude

    Résumé de l'étude

    The purpose of this study is to determine whether inspiratory muscle strength training reduces blood pressure in adults with obesity.

    Source : Importé depuis le centre

    Obesity affects four-in-ten American adults and is associated with hypertension and greater all-cause mortality. Irrespective of weight loss, aerobic exercise reduces arterial blood pressure (BP) and improves cardiometabolic health. However, nearly half of adults with obesity do not perform aerobic exercise because of low leisure time availability and exertional dyspnea secondary to high chest wall mass-related inspiratory muscle dysfunction. In other clinical populations, emerging data demonstrates time-efficient high-resistance inspiratory muscle strength training (IMST) reduces BP and improves respiratory muscle function. Therefore, the investigators will determine whether eight weeks of daily high-resistance IMST reduces BP, improves respiratory muscle function, and concomitantly reduces exertional dyspnea in a randomized, double-blinded, sham-controlled (i.e., very low-resistance IMST) clinical trial among adults with obesity

    Source : Importé depuis le centre

    Sites

    Centres participants

      1 centres
    • FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE

      Sarasota

      FLORIDA, UNITED STATES

      Recrutement local
      État du recrutement: OUVERT
      Coordonnées pour le recrutement
      Contacts locaux
      chercheurs:

    Dernière modification : 5 février 2025
    Données à jour depuis : 7 fév.
    Origine des données : clinicaltrials.gov
    Référence clinicaltrials.gov: NCT05459636