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29BRC23.0144 - SATIATION

Impact of dose to cardiac substructures on survival in patients with esophageal cancer treated with radiotherapy or chemoradiotherapy (satiation)
Source : Importé depuis le centre

Référence clinicaltrials.gov: NCT05996276
radiotherapy; cardiotoxicity
Source : Importé depuis le centre
Recrutement ouvert
Dernière modification : 2024/08/08
Type de recherche

Observationnel


Population cible

Condition médicale (spécialité visée)

Donnée non disponible

Profil des participants

Sexe(s) des participants

ALL

Source : Importé depuis le centre

Critères de sélection

Critères d'inclusion

Inclusion Criteria:

* Age ≥ 18 years
* Histologically or cytologically proven esophageal cancer
* Localized or locally advanced esophageal cancer treated with radiochemotherapy or exclusive radiotherapy
* Tumor dose ≥ 50 Gy
* Non-opposition of living patients formulated
* Patient affiliated to a social security scheme

Exclusion Criteria:

* Age \< 18 years
* Patient treated with upfront surgery
* Tumor dose \< 50 Gy
* Other concomitant neoplasia
* Metastatic patient
* Refusal to participate
* Patient under legal protection (guardianship, curatorship, etc...)

Source : Importé depuis le centre

Thérapie ou Intervention proposée

Cohortes
Donnée non disponible
Données à jour depuis : 8 août 2024

Description de l'étude

Résumé de l'étude

Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy.

The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and more studies are calling for the use of dosimetric parameters related to cardiac sub-structures to be integrated into clinical practice, rather than considering the heart as a whole.

With this in mind, the aim of this study is to define the parameters, particularly dosimetric ones linked to cardiac sub-structures, influencing survival in patients treated with exclusive radiotherapy or radiochemotherapy for esophageal cancer.

Source : Importé depuis le centre

Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy.

The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and more studies are calling for the use of dosimetric parameters related to cardiac sub-structures to be integrated into clinical practice, rather than considering the heart as a whole.

Although most of these data have been studied in populations with long-term follow-up, such as breast cancer, cardiac toxicity and the reduced survival it entails are also found in diseases such as esophageal cancer.

With this in mind, the aim of this study is to define the parameters, particularly dosimetric ones linked to cardiac sub-structures, influencing survival in patients treated with exclusive radiotherapy or radiochemotherapy for esophageal cancer.

Source : Importé depuis le centre

Sites

Centres participants


Dernière modification : 8 août 2024
Données à jour depuis : 10 août
Origine des données : clinicaltrials.gov
Référence clinicaltrials.gov: NCT05996276